No one should take more than 300 mcg per day of chromium without the supervision of a doctor. In people trying to lose weight, a double-blind study found that 600 mcg per day of niacin-bound chromium helped some participants lose more fat and less muscle. Chromium bisglycinate supplementation has been shown. 15 Whether these problems were caused by chromium picolinate or, if so, whether other forms of chromium might have the same effects at these high amounts remains unclear. Chromium picolinate showed an absorption rate of only 37.5 compared to chromium bisglycinate at 57.5. 14 A case of a muscle disease known as rhabdomyolysis appeared in a body builder who took 1200 mcg over 48 hours. 13 A case of anemia, liver dysfunction, and other problems appeared after four to five months of 1,200–2,400 mcg per day. A case of kidney failure appeared after taking 600 mcg per day for six weeks. Three single, unrelated cases of toxicity have been reported from use of chromium picolinate. 12 However, no published evidence supports this assertion. Another source claimed that there have been reports of mild heart rhythm abnormalities with excessive chromium ingestion. Yet it is often an ingredient in weight loss products. 11 However, chromium supplementation was not proven to be the cause of these problems. The weight loss claims for chromium polynicotinate have never been scientifically proven or even studied extensively. One report of severe illness (including liver and kidney damage) occurring in a person who was taking 1,000 mcg of chromium per day has been reported. Evidence Based Chromium Picolinate: What Are the Benefits What It Is Blood Sugar Hunger Weight Loss Food Sources Supplements Bottom Line Taking chromium picolinate may lower blood sugar. 9 In theory, these changes could increase the risk of cancer, but so far, chromium intake has not been linked to increased incidence of cancer in humans. 7, 8 Chromium picolinate can be altered by antioxidants or hydrogen peroxide in the body to a form that could itself create free radical damage. Best easy-to-swallow supplement: PurePremium Chromium Picolinate. Best budget-friendly supplement: NOW Foods GTF Chromium. One study suggested that chromium in very high concentrations in a test tube could cause chromosomal mutations in ovarian cells of hamsters. Best low dose supplement: Superior Labs Chromium Picolinate. While there are a few reports of people developing medical problems while taking chromium, a cause-effect relationship was not proven. Read honest and unbiased product reviews from our users. Chromium picolinate should not be used in place of medication prescribed for you by your doctor. Find helpful customer reviews and review ratings for Pure Chromium Polynicotinate Supplement - Made in USA - 200mcg + Vitamin B3 for Optimal Absorption, Veggie Cap, 14 Week Supply at. In supplemental amounts (typically 50–300 mcg per day), chromium has not been found to cause toxicity in humans. Chromium picolinate has been used in alternative medicine to treat chromium deficiency, as an aid to controlling blood sugar in people with diabetes or prediabetes, to lower cholesterol, and as a weight-loss supplement.
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